Be Part of Something Great!

The Life Sciences Division has an opportunity for a Computational Biologist Postdoctoral Fellow to participate in projects to characterize the time and dose dependencies of gene-expression response profiles after exposures of mammalian cells and tissues to low-dose ionizing radiation, to identify response pathways, and to identify co-regulatory determinants of susceptibility to genomic damage in irradiated cells.

As a Postdoc, you will:

• Participate in projects to characterize the time and dose dependencies of gene-expression response profiles after exposures of mammalian cells and tissues to low-dose ionizing radiation, to identify response pathways, and to identify co-regulatory determinants of susceptibility to genomic damage in irradiated cells.
• Conduct genomic-scale experiments of gene expression profiles in irradiated cells using gene-transcript microarrays with cells from human 2D or 3D cultures, and mouse tissues.
• Perform molecular validation of mRNA response patterns in irradiated cells.
• Apply and interpret biostatistical tools to identify time- and dose-dependent clusters and characterize their variability among tissue and cell types.
• Apply and interpret bioinformatics analyses of functions and pathways associated with radiation-responsive genes.
• Maintain an accurate and detailed laboratory notebook of all experiments performed
• Provide training and guidance to undergraduate and graduate students.
• Prepare results for publication in scientific journals and presentations at seminars and
  present research data at group meetings, seminars and conferences.

Key Success Factors

• Recent Ph.D. degree in computational biology, biophysics, or related field.
• At least two years of experience in research involving genomic structure, computational genomic analyses, and bioinformatics tools are required.
• Experience in analyzing data from genome-scaling expression technologies (gene-transcript and/or proteomic cellular analyses methods) is required.
• Training and understanding of biostatistics and genomic biology is required.
• Demonstrated ability to work with guidance of principal investigator and collaborators.
• Demonstrated ability to conduct experiments independently, maintain appropriate records and manage data.
• Excellent verbal and written communication skills.
• Proven ability to organize research results for publication.

Desired Traits

• Experience in various techniques used in molecular biology, immunostaining, RNA and DNA analysis, in mammalian cells.
• Experience in culture of human cells.

Notes

This a one-year term visiting computational postdoctoral appointment with a possibility of renewal contingent upon the availability of funding and satisfactory performance.

To apply:
http://cjo.lbl.gov/LBNLCareers/details.asp?jid=23116&p=1

Berkeley Lab is an affirmative action/equal opportunity employer committed to the development of a diverse workforce.

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